NEW STUDIES ADDED
Title: Epigenetic Modulation of Adult Hippocampal Neurogenesis by Extremely Low-Frequency Electromagnetic Fields
Location in PEMF Global Library: Stem Cell Folder, Neurological Folder
Applied Frequencies: 1-100 HZ, with a focus on 50Hz
Available in: iMRS Prime Trial
Abstract: Throughout life, adult neurogenesis generates new neurons in the dentate gyrus of hippocampus that have a critical role in memory formation. Strategies able to stimulate this endogenous process have raised considerable interest because of their potential use to treat neurological disorders entailing cognitive impairment. We previously reported that mice exposed to extremely low-frequency electromagnetic fields (ELFEFs) showed increased hippocampal neurogenesis. Here, we demonstrate that the ELFEF dependent enhancement of hippocampal neurogenesis improves spatial learning and memory
Conclusion: Our present study points to ELFEF stimulation as a good tool to enhance hippocampal neurogenesis and improve hippocampal-dependent memory functions in mice. The optimization of stimulation protocol and the characterization of ELFEF’s mechanisms at molecular levels in the animal model appear pivotal for translating results to humans. Our study identifies a novel molecular mechanism responsible for ELFEF-induced enhancement of hippocampal neurogenesis, which is of potential relevance for future stem cell-based therapeutic approaches. The discovery of the new CREB/NeuroD1 axis may be also relevant for treatment of brain disorders associated to alterations of these transcription factors.
NEW STUDIES ADDED
Title: Electromagnetic Fields for the Regulation of Neural Stem Cells
Location in PEMF Global Library: Stem Cell Folder
Applied Frequencies: .5-30 Hz
Available in: Omnium1 2.0, iMRS Prime
Abstract: Localized magnetic fields could easily penetrate the scalp, skull, and meninges, thus inducing an electrical current in both the central and peripheral nervous systems, which is primarily used in transcranial magnetic stimulation (TMS) for inducing specific effects on different regions or cells that play roles in various brain activities. Studies of repetitive transcranial magnetic stimulation (rTMS) have led to novel attractive therapeutic approaches. Neural stem cells (NSCs) in adult human brain are able to selfrenew and possess multi-differential ability to maintain homeostasis and repair damage after acute central nervous system. In the present review, we summarized the electrical activity of NSCs and the fundamental mechanism of electromagnetic fields and their effects on regulating NSC proliferation, differentiation, migration, and maturation. Although it was authorized for the rTMS use in resistant depression patients by US FDA, there are still unveiling mechanism and limitations for rTMS in clinical applications of acute central nervous system injury, especially on NSC regulation as a rehabilitation strategy. More in-depth studies should be performed to provide detailed parameters and mechanisms of rTMS in further studies, making it a powerful tool to treat people who are surviving with acute central nervous system injuries.
Conclusion: Despite its limitations, TMS is a promising therapeutic tool for many refractory neural diseases. It is non-invasive and has a clear positive influence on different parts of the brain, especially on NSCs. Nevertheless, NSCs are promising for traumatic, degenerative, and psychiatric diseases. All these findings contributed to TMS being deemed as a brain science technology of the 21st century. Clinical applications must be expanded to collect more data regarding the modality. We believe that the efforts of excellent researchers will accelerate the development of TMS applications, making it a powerful tool to treat people who are surviving with painful diseases.
NEW STUDIES ADDED
Title: Effects of electromagnetic fields on bone regeneration in experimental and clinical studies: a review of the literature
Location in PEMF Global Library: Bone density, fractures, breaks and Tissue Regeneration Folder
Applied Frequencies: Emphasis on 50Hz
Available in: iMRS Prime
Abstract: To assess the experimental and clinical data regarding the effects of electromagnetic fields (EMFs) on fracture non-union. Articles were included in the review if they were related to the use of EMFs on BMSCs or bone tissue.
Conclusion: Experimental and clinical studies suggest that EMFs would be an ideal therapy for bone regeneration because of the action on bone tissue related cell metabolism that has been demonstrated in vitro and in vivo. Based on the previously mentioned effects of EMFs on bone tissue related cell culture, it could be hypothesized that stimulation might accelerate and ameliorate both expansion and redifferentiation.