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Scientific Sunday Series

6/5/2022

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Adenosine...


Title: Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts

Location in PEMF Global Library: Adenosine folder
Published: 2008

Applied Frequencies: 75 Hz
Available in: iMRS Prime Trial
 
Abstract: To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E2 (PGE2) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs).
 
Conclusion: This study supports anti-inflammatory activities of A1 and A2A adenosine receptors and EMFs in bovine SFs. EMF activity appears mediated by an EMF-induced up-regulation of A2A receptors.


Title: Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields

Location in PEMF Global Library: Adenosine folder
Published: February 2017

Applied Frequencies: 10-120 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: By reviewing the scientific literature on joint cells, a double role for PEMFs could be hypothesized in vitro by stimulating cell proliferation, colonization of the scaffold, and production of tissue matrix.
 
Conclusion: The results reported in this review highlight that the increase of A2A and A3ARs induced by PEMFs in different cells involves a reduction of some of the most relevant proinflammatory cytokines. Of particular interest is the observation that the PEMFs determine an increased functioning of the endogenous agonist adenosine, a potent modulator of various physiological and pathological responses.

Title: Dose-Dependent ATP Depletion and Cancer Cell Death following Calcium Electroporation,
Relative Effect of Calcium Concentration and Electric Field Strength
​
Location in PEMF Global Library: Adenosine folder
Published: April 2015

Applied Frequencies: 1 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: This study aims at understanding the relationship between applied electric field, calcium concentration, ATP depletion and efficacy.
 
Conclusion: Calcium electroporation dose-dependently reduced cell survival and intracellular ATP. Increasing extracellular calcium allows the use of a lower electric field.


Title: Effect of electromagnetic field on cyclic adenosine monophosphate (cAMP) in a human mu-opioid receptor cell model

Location in PEMF Global Library: Adenosine folder
Published: December 2015

Applied Frequencies: 5 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: Resonance responses to biological systems using exogenous EMF signals suggest that frequency response characteristics of the target can determine the EMF biological response. In our past research we found significant down regulation of inflammatory markers tumor necrosis factor alpha (TNF-α) and nuclear factor kappa B (NFκB) using 5 Hz EMF frequency.
 
Conclusion: This study suggests the use of EMF as a complementary or alternative treatment to morphine that could both reduce pain and enhance patient quality of life without the side-effects of opiates.

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