Tissue Regeneration...Title: Electromagnetic fields as first messenger in biological signaling: Application to calmodulin-dependent signaling in tissue repair Location in PEMF Global Library: Tissue Regeneration Folder Published: October 2011 Applied Frequencies: 27.12 Hz Available in: Omnium1, iMRS Prime Trial Abstract: This study proposes that an EMF can act as a first messenger in the calmodulin-dependent signaling pathways that orchestrate the release of cytokines and growth factors in normal cellular responses to physical and/or chemical insults. Conclusion: Configured EMF signals modulated CaM-dependent enzyme kinetics, produced several-fold increases in key second messengers to include nitric oxide and cyclic guanosine monophosphate in chondrocyte and endothelial cultures and cyclic adenosine monophosphate in neuronal cultures. Calmodulin antagonists and downstream blockers annihilated these effects, providing strong support for the proposed mechanism. Title: Mechanical Stimulation (Pulsed Electromagnetic Fields “PEMF” and Extracorporeal Shock Wave Therapy “ESWT”) and Tendon Regeneration: A Possible Alternative Location in PEMF Global Library: Tissue Regeneration Folder Published: November 2015 Applied Frequencies: 5-600 Hz Available in: Omnium1, iMRS Prime Trial Abstract: In this manuscript the rational of mechanical stimulations and the clinical studies on the efficacy of extracorporeal shock wave (ESW) and PEMF will be discussed. Conclusion: No clear evidence of a clinical value of ESW and PEMF has been found in literature with regards to the treatment of tendinopathy in human, so further clinical trials are needed to confirm the promising hypotheses concerning the effectiveness of ESWT and PEMF mechanical stimulation. Title: PHYSIOLOGICAL AND MOLECULAR GENETIC EFFECTS OF TIME-VARYING ELECTROMAGNETIC FIELDS ON HUMAN NEURONAL CELLS Location in PEMF Global Library: Tissue Regeneration Folder Published: 2003 Applied Frequencies: 10 Hz Available in: Omnium1, iMRS Prime Trial Abstract: The present investigation details the development of model systems for growing two- and three-dimensional human neural progenitor cells within a culture medium facilitated by a time-varying electromagnetic field (TVEMF). Conclusion: In both experimental configurations, the proliferation rate of the TVEMF cells was 2.5 to 4.0 times the rate of the non-waveform cells. Each of the experimental embodiments resulted in similar molecular genetic changes regarding the growth potential of the tissues as measured by gene chip analyses, which measured more than 10,000 human genes simultaneously. Title: Electromagnetic Field Stimulation Potentiates Endogenous Myelin Repair by Recruiting Subventricular Neural Stem Cells in an Experimental Model of White Matter Demyelination Location in PEMF Global Library: Tissue Regeneration Folder Published: May 2012 Applied Frequencies: 60 Hz Available in: iMRS Prime Trial Abstract: The aim of this study was to assess the effects of EMFs on the process of toxin-induced demyelination and subsequent remyelination. Conclusion: EMFs significantly reduced the extent of demyelinated area and increased the level of MBP staining within the lesion area on days 14 and 28 postlesion. EMFs also increased the number of BrdU- and nestin-positive cells within the area between SVZ and lesion as observed on days 7 and 14 postlesion. It seems that EMF potentiates proliferation and migration of neural stem cells and enhances the repair of myelin in the context of demyelinating conditions. If you are interested in reading any of these studies in their entirety, please contact us stating the studies you are interested in.
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