Stroke...Title: Effect of Pulsed Electromagnetic Field (PEMF) on Infarct Size and Inflammation After Cerebral Ischemia in Mice Location in PEMF Global Library: Stroke folder Published: 2014 Applied Frequencies: 2 Hz Available in: Omnium1, iMRS Prime Trial Abstract: We studied the effect of PEMF on infarct size and poststroke inflammation following distal middle cerebral artery occlusion (dMCAO) in mice. Conclusion: PEMF application significantly downregulated genes encoding members of the major pro-apoptotic tumor necrosis factor (TNF) superfamily indicating that the treatment could have both anti-inflammatory and anti-apoptotic effects. Both reduction of infarct size and influence on neuroinflammation could have a potentially important positive impact on the poststroke recovery process, implicating PEMF as a possible adjunctive therapy for stroke patients. Title: Increases in microvascular perfusion and tissue oxygenation via pulsed electromagnetic fields in the healthy rat brain Location in PEMF Global Library: Stroke folder Published: October 2014 Applied Frequencies: 5 Hz Available in: Omnium1, iMRS Prime Trial Abstract: The authors hypothesized that in the brain, PEMF increase nitric oxide (NO), which induces vasodilation, enhances microvascular perfusion and tissue oxygenation, and may be a useful adjunct therapy in stroke and traumatic brain injury. To test this hypothesis, they studied the effect of PEMF on a healthy rat brain with and without NO synthase (NOS) inhibition. Conclusion: Pulsed electromagnetic field stimulation significantly dilated cerebral arterioles from a baseline average diameter of 26.4 ± 0.84 µm to 29.1 ± 0.91 µm (11 rats, p < 0.01). Increased blood volume flow through dilated arterioles enhanced capillary flow with an average increase in RBC flow velocity by 5.5% ± 1.3% (p < 0.01). Enhanced microvascular flow increased tissue oxygenation as reflected by a decrease in NADH autofluorescence to 94.7% ± 1.6% of baseline (p < 0.05). Nitric oxide synthase inhibition by L-NAME prevented PEMF-induced changes in arteriolar diameter, microvascular perfusion, and tissue oxygenation (7 rats). No changes in measured parameters were observed throughout the study in the untreated time controls (5 rats). Title: Low Frequency Repetitive Transcranial Magnetic Stimulation to Improve Motor Function and Grip Force of Upper Limbs of Patients With Hemiplegia Location in PEMF Global Library: Stroke folder Published: August 2014 Applied Frequencies: 1 Hz Available in: Omnium1, iMRS Prime Trial Abstract: The aim of this study is to determine the effects of rTMS plus routine rehabilitation on hand grip and wrist motor functions in patients with hemiplegia, and compare with pure routine rehabilitation programs. Conclusion: rTMS can improve hand muscle force and functions of patients with chronic hemiplegia, while conventional treatment is not effective. Title: An Open Label, One Arm, Dose Escalation Study to Evaluate The Safety of Extremely Low Frequency Magnetic Fields in Acute Ischemic Stroke Location in PEMF Global Library: Stroke folder Published: June 2014 Applied Frequencies: 75 Hz Available in: iMRS Prime Trial Abstract: Main purpose of this open label, one arm, dose escalation study is the validation of ELF-MF stimulation as non-invasive and safe tool to promote recovery in acute ischemic stroke patients. Conclusion: In conclusion, ELF-MFs have been shown to modulate the main mechanisms of brain ischemic damage and regeneration in in-vitro and in-vivo animal models. Preliminary results in humans suggest that ELF-MF stimulation is safe. Want complete access to the library?
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