SCIENTIFIC SUNDAY SERIES

NEW STUDIES ADDED

---

Title:  Time-Varying and Static Magnetic Fields in Therapeutic Applications: From Mechanisms to Clinical Results

Location in PEMF Global Library: General folder
Published: 2000
​
Applied Frequencies: 27.12 MHz

Conclusion: The analyses presented in this study strongly suggest that, if ion/ligand binding with known kinetics is the EMF sensitive target, any pulsing or static magnetic field may be predictively configured to achieve the correct dosimetry for a physiologically meaningful bioeffect. This may provide part of the basis of a unified theory for weak EMF bioeffects.

---

Title:  Pulsed electromagnetic fields for the treatment of tibial delayed unions and non-union. A prospective clinical study and review of the literature

Location in PEMF Global Library: Bone Density, fractures, breaks folder
Published: 2012

Applied Frequencies: not listed
Available in: NA
 
Abstract: Pulsed electromagnetic fields (PEMF) stimulation for the treatment of bone non-union or delayed union have been in use for several years, but on a limited basis. The aim of this study was to assess the overall efficacy of the method in tibial delayed unions and non-union and identify factors that could affect the outcome.
​
Conclusion: Conclusion: PEMF stimulation is an effective non-invasive method for addressing non-infected tibial union abnormalities. Its success is not associated with specific fracture or patient related variables, and it couldn’t be clearly considered a time-dependent phenomenon.

---

Title: Extremely Low-Frequency Electromagnetic Fields Affect Transcript Levels of Neuronal Differentiation-Related Genes in Embryonic Neural Stem Cells

Location in PEMF Global Library: Stem Cell folder, Embryo folder
Published: 2014

Applied Frequencies: 50Hz
Available in: iMRS Prime Trial
 
Abstract:  Previous studies have reported that extremely low-frequency electromagnetic fields (ELF-EMF) can affect the processes of brain development, but the underlying mechanism is largely unknown. The proliferation and differentiation of embryonic neural stem cells (eNSCs) is essential for brain development during the gestation period. To date, there is no report about the effects of ELF-EMF on eNSCs. In this paper, we studied the effects of ELF-EMF on the proliferation and differentiation of eNSCs. Primary cultured eNSCs were treated with 50 Hz ELF-EMF; various magnetic intensities and exposure times were applied. Our data showed that there was no significant change in cell proliferation, which was evaluated by cell viability (CCK-8 assay), DNA synthesis (Edu incorporation), average diameter of neurospheres, cell cycle distribution (flow cytometry) and transcript levels of cell cycle related genes (P53, P21 and GADD45 detected by real-time PCR). When eNSCs were induced to differentiation, real-time PCR results showed a down-regulation of Sox2 and up-regulation of Math1, Math3, Ngn1 and Tuj1 mRNA levels after 50 Hz ELF-EMF exposure (2 mT for 3 days), but the percentages of neurons (Tuj1 positive cells) and astrocytes (GFAP positive cells) were not altered when detected by immunofluorescence assay. Although cell proliferation and the percentages of neurons and astrocytes differentiated from eNSCs were not affected by 50 Hz ELF-EMF, the expression of genes regulating neuronal differentiation was altered.
​
Conclusion: In conclusion, our results support that 50 Hz ELF EMF induce molecular changes during eNSCs differentiation, which might be compensated by post-transcriptional mechanisms to support cellular homeostasis.

---

Title:  A Non-Operative Salvage of Surgically- Resistant Pseudarthrosis and Non- Unions by Pulsing Electromagnetic Fields

Location in PEMF Global Library: Bone Density, fractures, breaks folder
Published: 1977

Applied Frequencies: 75 Hz
Available in: iMRS Prime Trial
 
Abstract: This report documents, for the first time, to the author’s knowledge, the therapeutic use in humans of low energy, EMFs pulsing in the extremely low frequency (ELF) range.  These field, established out-side the body, were used to treat congenital and acquired pseudoarthrosis and non-unions.  Energy of this type appears to affect biological processes, not through heat production, but through electrically induced changes in the environment of cells within the organism.  Of the 29 patients included in the study, 17 had experienced at least one failure of surgical repair and, in each of these, amputation had been recommended.  The overall success rate, including those patients treated with inadequate pulse characteristics and those who failed to follow the protocol, was more than 70 percent.  Improvements in the specificity of pulse characteristics hold promise for increasing the rate of success.
​