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Scientific Sunday Series

5/29/2022

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Epilepsy...


Title: A Randomized Clinical Trial of Repetitive Transcranial Magnetic Stimulation in patients with Refractory Epilepsy

Location in PEMF Global Library: Epilepsy folder
Published: 2006

Applied Frequencies: 1 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: To study the antiepileptic effects of rTMS in patients with refractory epilepsy and malformations of cortical development in a randomized, double-blind, sham-controlled trial.
 
Conclusion: Noninvasive brain stimulation for epilepsy may be an alternative treatment for pharmaco-resistant patients with clearly identifiable seizure foci in the cortical convexity and who are not eligible for surgical treatment.


Title: Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainite status epilepticus model

Location in PEMF Global Library: Epilepsy folder
Published: July 2016

Applied Frequencies: ≤1 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: We aimed to test the antiepileptic potential of high-frequency rTMS in SE. As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model.
 
Conclusion: We report that high-frequency rTMS has modest antiepileptic potential alone but acts in complement with lorazepam to suppress seizures.

Title: Effects of Applied Electric Fields on Low-Calcium Epileptiform Activity in the CA1 Region of Rat Hippocampal Slices

Location in PEMF Global Library: Epilepsy folder
Published: March 2000

Applied Frequencies: 1 kHz
Available in: iMRS Prime Trial
 
Abstract: We tested the hypothesis that low-calcium bursting induced in the CA1 region of transverse and longitudinal hippocampal slices should be highly sensitive to exogenous electric fields.
 
Conclusion: These results suggest that DC fields modulate and suppress low-calcium activity by directly polarizing CA1 pyramidal cells.


Title: Low-frequency repetitive transcranial magnetic stimulation for seizure suppression in patients
with extratemporal lobe epilepsy–—A pilot study

Location in PEMF Global Library: Epilepsy folder
Published: 2005

Applied Frequencies: 0.9 Hz
Available in: Omnium1, iMRS Prime Trial
 
Abstract: We evaluated the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure frequency in adult patients with medically intractable extratemporal lobe epilepsy (ETLE).
 
Conclusion: After low-frequency rTMS of one week, the frequency of all seizure types, complex partial seizures (CPSs) and simple partial seizures was reduced by 19.1, 35.9 and 7.4%, respectively. The patients with smaller difference between RMT and AMT before rTMS had higher reduction rate of CPSs.

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