NEW STUDIES ADDED
Title: Effects of electromagnetic fields on bone regeneration in experimental and clinical studies: a review of the literature
Location in PEMF Global Library: Bone density, fractures, breaks and Tissue Regeneration Folder
Applied Frequencies: Emphasis on 50Hz
Available in: iMRS Prime
Abstract: To assess the experimental and clinical data regarding the effects of electromagnetic fields (EMFs) on fracture non-union. Articles were included in the review if they were related to the use of EMFs on BMSCs or bone tissue.
Conclusion: Experimental and clinical studies suggest that EMFs would be an ideal therapy for bone regeneration because of the action on bone tissue related cell metabolism that has been demonstrated in vitro and in vivo. Based on the previously mentioned effects of EMFs on bone tissue related cell culture, it could be hypothesized that stimulation might accelerate and ameliorate both expansion and redifferentiation.
Title: How Does Transcranial Magnetic Stimulation Influence Glial Cells in the Central Nervous System?
Location in PEMF Global Library: Nervous System Folder
Applied Frequencies: 1-30Hz
Available in: Omnim1 2.0, iMRS Prime
Abstract: Transcranial magnetic stimulation (TMS) is widely used in the clinic, and while it has a direct effect on neuronal excitability, the beneficial effects experienced by patients are likely to include the indirect activation of other cell types. Research conducted over the past two decades has made it increasingly clear that a population of non-neuronal cells, collectively known as glia, respond to and facilitate neuronal signaling. Each glial cell type can respond to electrical activity directly or indirectly, making them likely cellular effectors of TMS. TMS has been shown to enhance adult neural stem and progenitor cell (NSPC) proliferation, but the effect on cell survival and differentiation is less certain. Furthermore, there is limited information regarding the response of astrocytes and microglia to TMS, and a complete paucity of data relating to the response of oligodendrocyte-lineage cells to this treatment. However, due to the critical and yet multifaceted role of glial cells in the central nervous system (CNS), the influence that TMS has on glial cells is certainly an area that warrants careful examination.
Conclusion: The use of TMS and other activity-based therapies is increasing, and despite the important role played by glial cells in responding to activity and regulating activity in the CNS, they have been largely overlooked in this field, with only a small number of studies examining the role of TMS on glia in vivo. It is likely that many of the beneficial effects of TMS are the result of the secondary activation of glial cells. To fully understand the therapeutic benefits that can be obtained through the application of TMS, it will be critical to understand which stimulation patterns most influence glial cell populations, perhaps even opening previously unconsidered therapeutic options for the use of TMS to manipulate glial cell function
Title: REGENERATIVE EEFECTS OV PULSED MAGNETIC FIELD ON INJURED PERIPHERAL NERVES
Location in PEMF Global Library: Nerve and Neuropathy, Tissue Regeneration Folder
Applied Frequencies: 1,10,40 & Hz
Available in: Omnium1 2.0 & iMRS Prime, iMRS Prime Trial
Abstract: Previous studies confirm that pulsed magnetic field (PMF) accelerates functional recovery after a nerve crush lesion. The influence of a new PMF application protocol (trained PMF) on nerve regeneration was studied in a model of crush injury of the sciatic nerve of rats. To determine if exposure to PMF influences regeneration, we used electrophysiological recordings and ultrastructural examinations.
Conclusion: PMF treatment during the 38 days following the crush injury enhanced the regeneration. Long-periodic trained-PMF may promote both morphological and electrophysiological properties of the injured nerves, in addition, corrective effects of PMF on sensory fibers may be considered an important finding for neuropathic pain therapy.
Title: TREATMENT OF DELAYED UNION AND PSEUDARTHROSIS BY LOW FREQUENCY PULSING ELECTROMAGNETIC STIMULATION
Location in PEMF Global Library: Bone Density, Fractures, Breaks Folder
Applied Frequencies: 75 Hz
Available in: iMRS Prime Trial
Abstract: This is a study of 35 cases of delayed union or established fibrous union (« pseudarthrosis ») treated by pulsing electromagnetic stimulation. The treatment, applied up to 12 hours per day, can be carried out at home, with clinical and radiological control every 60 days.
Conclusion: Union was obtained in 31 cases (88.5%) in all of which the clinical and radiological tests were unequivocal. The average time to achieve union was 6 months, with a range of 4-13 months. There were 3 re-fractures, all of which occurred within 3 months of the union and showed the typical characteristics of fatigue fractures. They were all cured by a further period of plaster fixation and electromagnetic stimulation for 35 days. It has been demonstrated that electromagnetic therapy can favourably influence reparative processes in all tissues – bone, cartilage, nerve, vascular – and this opens up new prospects for the future use of this method in a variety of fields, particularly in the treatment of fresh fractures.